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KMID : 0861020030180040263
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Korea Journal of Herbology
2003 Volume.18 No. 4 p.263 ~ p.268
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Acceleration of Wound Healing on Scald Burn Skin Using Irradiation of TDP and Skin Spread of Myrrha
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Lee Bok-Kyu
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Abstract
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Objectives : The present study was conducted to determine whether skin spread of Myrrha and Tending Diancibo Pu (TDP) irradiation have an remarkable effect on the cell regeneration as well as wound healing following dermal scald bum injury.
Methods : After bum injury, keratinocyte growth factor (KGF) level was analyzed immunologically in conjunction with the histological changes occurred in skin tissue.
Results : Scald burn induced the change of vascular permeability decreases the protein concentration in serum. Myrrha application and TDP irradiation significantly inhibited the loss of protein in it. The KGF contents in Myrrha application and TDP irradiation, which shows cell regeneration ability in skin tissue after bum, noticeably increased both at 24 h and at 48 h after burn. The content of KGF at 48 h is higher than that of at 24 h. Together with the result of histological changes, epithelial regeneration and dermal collagen synthesis from fibroblasts are accelerated in Mynha and TDP treated group compared to control group at same time postbum. At 48 h after bum, all dermal connective tissues are recovered to new collagen fibers in Myrrha and TDP treated group.
Conclusions : The data suggest that the compound treatment which is skin spread of Myrrha and TDP irradiation has an effect of accelerate cell regeneration and wound healing in case of scald bum skin by spreading of paste.
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